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Acute or Chronic Ache. Caution ought to be exercised when barbiturates are administered to sufferers with acute or Long-term discomfort, mainly because paradoxical pleasure may very well be induced or critical indications may very well be masked.Anticoagulants. Phenobarbital lowers the plasma levels of dicumarol and causes a decrease in anticoagula

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Phenytoin, Sodium Valproate, Valproic Acid. The influence of barbiturates on the metabolism of phenytoin appears to generally be variable. Some investigators report an accelerating result, whereas Other people report no effect. Because the impact of barbiturates about the metabolism of phenytoin will not be predictable, phenytoin and barbiturate bl

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